Fanconi Syndrome
Fanconi Syndrome is a hereditary kidney disorder causing the kidneys to lose essential nutrients in the urine, leading to progressive kidney dysfunction.
Detailed Description
Fanconi Syndrome is caused by a defect in the proximal renal tubules, resulting in the loss of glucose, amino acids, bicarbonate, and other solutes in the urine. This leads to excessive thirst, urination, weight loss, and, if untreated, kidney failure. Early detection and management can significantly improve quality of life.
Common Symptoms
- Excessive drinking
- Excessive urination
- Glucosuria
- Weight loss
- Muscle wasting
- Lethargy
- Occasional vomiting
Management Options
- Supportive care with bicarbonate and potassium supplementation
- Dietary management
- Strict monitoring of hydration and electrolytes
Frequently Asked Questions
Is Fanconi Syndrome curable?
No, but it can be managed with supportive care and early intervention.
How is Fanconi Syndrome inherited?
It is inherited in an autosomal recessive manner; both parents must carry the gene.
Condition Details
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Typical Age of Onset
4 to 8 years
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Testing Available
Yes
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Diagnosing Methods
Urinalysis; Blood tests for electrolyte imbalances; Genetic testing for FAN1 mutation
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Preventative Measures
Genetic testing of breeding stock; Avoid breeding carriers or affected dogs
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Related Conditions
Diabetes mellitus, Other forms of renal disease