Spinocerebellar Ataxia
Spinocerebellar ataxia (SCA) is a hereditary neurodegenerative disorder causing progressive loss of coordination and severe motor dysfunction, typically with early onset in puppies.
Detailed Description
SCA results from degeneration of the spinal cord and cerebellum, leading to ataxia, tremors, and loss of motor control. The disease is progressive and fatal, with affected puppies often euthanized before one year of age. It is caused by a mutation in the KCNJ10 gene and is inherited in an autosomal recessive manner.
Common Symptoms
- Severe incoordination
- Tremors
- Difficulty standing
- Rapid progression
Management Options
- Supportive care
Frequently Asked Questions
How is SCA different from LOA?
SCA has an earlier onset and is caused by a different mutation.
Can SCA be prevented?
Yes, through genetic testing and responsible breeding.
Is there a cure for SCA?
No, only supportive care is possible.
How quickly does SCA progress?
Rapidly; most affected puppies are euthanized before 1 year.
Are carriers affected?
No, only homozygous dogs are affected.
Condition Details
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Typical Age of Onset
2 to 6 months
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Testing Available
Yes
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Diagnosing Methods
Neurological examination; Genetic testing; MRI (to rule out other causes)
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Preventative Measures
Genetic testing of breeding stock; Avoid breeding carriers or affected dogs
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Related Conditions
Late-Onset Ataxia, Other cerebellar disorders