Pyruvate Kinase Deficiency
Pyruvate Kinase Deficiency (PKD) is a hereditary disorder causing chronic hemolytic anemia due to an enzyme deficiency in red blood cells.
Detailed Description
PKD results from a deficiency of the enzyme pyruvate kinase, leading to premature destruction of red blood cells and resulting in anemia. Affected dogs may show pallor, lethargy, and exercise intolerance. The disease is progressive and can be life-limiting.
Common Symptoms
- Lethargy
- Weakness
- Exercise intolerance
- Pale mucous membranes
- Splenomegaly
- Jaundice
Management Options
- Supportive care including blood transfusions
- Splenectomy in some cases
- Avoidance of stress and infections
Frequently Asked Questions
Can PKD be cured?
No, only supportive care is available.
How is PKD inherited?
PKD is inherited in an autosomal recessive manner.
Condition Details
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Typical Age of Onset
4 months to 2 years
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Testing Available
Yes
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Diagnosing Methods
Complete blood count (CBC); Enzyme assay for pyruvate kinase activity; Genetic testing
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Preventative Measures
Genetic testing of breeding stock; Avoid breeding carriers or affected dogs
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Related Conditions
Immune-mediated hemolytic anemia, Other hereditary anemias