Pyruvate Dehydrogenase Phosphatase 1 Deficiency
Pyruvate Dehydrogenase Phosphatase 1 (PDP1) Deficiency is a rare inherited metabolic disorder causing exercise intolerance and collapse, particularly in Clumber and Sussex Spaniels.
Detailed Description
PDP1 deficiency impairs energy metabolism in muscle cells, leading to weakness and collapse after exercise. It is caused by a mutation in the PDP1 gene and is unique to certain spaniel breeds. Affected dogs recover rapidly with rest, and the condition is managed by avoiding strenuous activity.
Common Symptoms
- Weakness after exercise
- Collapse after exercise
- Rapid recovery with rest
Management Options
- Avoidance of strenuous exercise
Frequently Asked Questions
Can PDP1 deficiency be cured?
No, but symptoms can be managed by limiting exercise.
Should all dogs in affected breeds be tested?
Yes, especially breeding dogs.
Is this the same as EIC in Labradors?
No, it is a different genetic mutation.
Condition Details
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Typical Age of Onset
Young dogs (as soon as exercise is attempted)
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Testing Available
Yes
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Diagnosing Methods
DNA test; Clinical history; Exclusion of other causes
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Preventative Measures
Genetic testing of breeding stock
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Related Conditions
Exercise-induced collapse in Labradors, Cardiac arrhythmias