Neuronal Ceroid Lipofuscinosis
Neuronal ceroid lipofuscinosis (NCL) is a fatal, inherited neurodegenerative disorder causing progressive neurological decline.
Detailed Description
NCL is caused by mutations in the canine CLN5 gene, leading to accumulation of lipopigments in neurons. Affected dogs develop behavioral changes, vision loss, ataxia, and seizures, progressing to severe neurological impairment and death.
Common Symptoms
- Behavioral changes (anxiety, confusion)
- Ataxia (uncoordinated movement)
- Vision loss
- Seizures
Management Options
- Supportive care only
Frequently Asked Questions
Can NCL be treated?
No, there is no effective treatment.
How is NCL inherited?
Autosomal recessive; both parents must be carriers.
Can NCL be prevented?
Yes, through genetic testing and responsible breeding.
Condition Details
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Typical Age of Onset
18 months to 3 years
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Testing Available
Yes
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Diagnosing Methods
Clinical signs; MRI (brain atrophy); Genetic testing; Post-mortem histopathology
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Preventative Measures
DNA testing of breeding stock; Avoid breeding carriers
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Related Conditions
Epilepsy, Other neurodegenerative diseases