Late-Onset Ataxia
Late-onset ataxia (LOA) is a hereditary neurological disorder in dogs that causes progressive loss of coordination and balance, typically manifesting in young adulthood.
Detailed Description
LOA is characterized by degeneration of the cerebellum, leading to uncoordinated movements, tremors, and difficulty walking. The disease is progressive and ultimately leads to severe disability and euthanasia. It is caused by a mutation in the CAPN1 gene and is inherited in an autosomal recessive manner.
Common Symptoms
- Wobbly gait
- Loss of balance
- Head tremors
- Difficulty standing
Management Options
- Supportive care
- Euthanasia as disease progresses
Frequently Asked Questions
Can LOA be cured or managed long-term?
No, there is no cure and supportive care is limited.
How is LOA inherited?
Autosomal recessive; both parents must be carriers.
Is there a test for LOA?
Yes, a DNA test is available.
How quickly does LOA progress?
Symptoms worsen over months; most affected dogs are euthanized before age 2.
Can carriers show symptoms?
No, only dogs with two copies of the mutation are affected.
Condition Details
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Typical Age of Onset
6 months to 1 year
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Testing Available
Yes
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Diagnosing Methods
Neurological examination; Genetic testing; MRI (to rule out other causes)
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Preventative Measures
Genetic testing of breeding stock; Avoid breeding carriers or affected dogs
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Related Conditions
Spinocerebellar ataxia, Early-onset ataxia