Juvenile Myoclonic Epilepsy
Juvenile myoclonic epilepsy (JME) is a hereditary epilepsy syndrome characterized by myoclonic seizures in young dogs.
Detailed Description
JME is caused by a mutation in the DIRAS1 gene, leading to frequent myoclonic jerks and, in some cases, generalized tonic-clonic seizures. It is inherited in an autosomal recessive manner and typically manifests in puppies and young dogs.
Common Symptoms
- Myoclonic jerks (sudden muscle contractions)
- Generalized seizures
- Jerking movements during rest or sleep
Management Options
- Antiepileptic drugs (levetiracetam, phenobarbital)
- Lifelong management
Frequently Asked Questions
Is JME fatal?
No, but requires lifelong medication.
Can JME be prevented?
Yes, through genetic testing and responsible breeding.
Are all seizures in Ridgebacks JME?
No, but JME is the most common hereditary epilepsy in the breed.
What is the prognosis?
Good with treatment; most dogs live normal lives.
Is JME unique to Ridgebacks?
The specific mutation is breed-specific.
Condition Details
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Typical Age of Onset
6 weeks to 18 months (median ~6 months)
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Testing Available
Yes
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Diagnosing Methods
Clinical history; Video EEG; Genetic testing
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Preventative Measures
Genetic testing of breeding dogs; Avoid carrier-to-carrier matings
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Related Conditions
Other forms of epilepsy, Movement disorders