Juvenile Laryngeal Paralysis and Polyneuropathy
A severe, inherited neurological disorder causing progressive nerve degeneration, primarily affecting young dogs.
Detailed Description
JLPP is caused by a mutation in the RAB3GAP1 gene, leading to degeneration of peripheral nerves and laryngeal muscles. Affected puppies develop voice changes, difficulty breathing, and progressive weakness, often resulting in early euthanasia.
Common Symptoms
- Change in bark
- Noisy breathing (stridor)
- Exercise intolerance
- Hind limb weakness
- Difficulty swallowing
Management Options
- Supportive care
Frequently Asked Questions
Can JLPP be prevented?
Yes, through DNA testing and responsible breeding.
Is JLPP treatable?
No, it is fatal in affected puppies.
Should all dogs be tested for JLPP?
All breeding dogs must be tested; pet dogs do not require testing if parents are clear.
Condition Details
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Typical Age of Onset
2–6 months
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Testing Available
Yes
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Diagnosing Methods
DNA testing; Neurological examination; Laryngoscopy
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Preventative Measures
DNA testing and breeding only clear or carrier-to-clear pairs
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Related Conditions
Acquired laryngeal paralysis, Other polyneuropathies