Hereditary Hemolytic Anemia
Hereditary hemolytic anemia, often due to pyruvate kinase deficiency, is a rare but serious inherited red blood cell disorder causing chronic anemia in dogs.
Detailed Description
Pyruvate kinase (PK) deficiency is a hereditary enzyme deficiency that impairs red blood cell metabolism, leading to premature destruction of red blood cells (hemolysis). Affected dogs develop chronic, regenerative anemia, exercise intolerance, and may have a shortened lifespan due to progressive anemia and secondary complications.
Common Symptoms
- Lethargy
- Pale mucous membranes
- Exercise intolerance
- Splenomegaly
Management Options
- Supportive care (transfusions, management of anemia)
- Splenectomy (temporary relief)
Frequently Asked Questions
How is PK deficiency inherited?
It is inherited in an autosomal recessive manner; both parents must be carriers.
Can PK deficiency be cured?
No, only supportive care is available.
How can I prevent PK deficiency in my puppies?
Test breeding dogs and avoid carrier-to-carrier matings.
What are the first signs of PK deficiency?
Lethargy and pale gums in young dogs.
Is PK deficiency common in dogs?
It is rare overall, but some breeds have higher carrier rates.
Condition Details
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Typical Age of Onset
6 months to 2 years
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Testing Available
Yes
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Diagnosing Methods
CBC showing regenerative anemia; DNA testing for PK mutation
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Preventative Measures
Genetic testing of breeding stock; Avoid breeding carriers
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Related Conditions
Immune-mediated hemolytic anemia, Other causes of anemia