GM1 Gangliosidosis
GM1 Gangliosidosis is a rare, fatal inherited neurodegenerative disorder in dogs caused by a deficiency of the enzyme beta-galactosidase.
Detailed Description
This lysosomal storage disease results from a deficiency of the enzyme beta-galactosidase, leading to accumulation of GM1 ganglioside in neurons and other tissues. Affected puppies develop progressive neurological symptoms and die before 2 years of age.
Common Symptoms
- Ataxia
- Tremors
- Vision loss
- Seizures
- Behavioral changes
- Progressive weakness
Management Options
- Supportive care
Frequently Asked Questions
Is GM1 gangliosidosis still a problem?
Rare now due to genetic testing.
Can it be cured?
No cure exists.
How is it prevented?
Through DNA testing of breeding dogs.
What are the first signs?
Unsteady gait and behavioral changes in puppies.
Is it painful?
It causes severe neurological impairment.
Condition Details
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Typical Age of Onset
5–6 months
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Testing Available
Yes
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Diagnosing Methods
Genetic testing; Enzyme assay; Clinical signs; Post-mortem histopathology
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Preventative Measures
Genetic testing; Exclusion of carriers from breeding
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Related Conditions
Other lysosomal storage diseases, Cerebellar abiotrophy