Glanzmann Thrombasthenia
A rare, inherited bleeding disorder caused by defective platelet aggregation, leading to abnormal bleeding.
Detailed Description
Glanzmann thrombasthenia is an autosomal recessive disorder caused by mutations in the ITGA2B gene, resulting in defective platelet glycoprotein IIb/IIIa. Affected dogs experience spontaneous or excessive bleeding after injury or surgery.
Common Symptoms
- Prolonged bleeding after injury or surgery
- Spontaneous nosebleeds
- Gum bleeding
- Bruising
- Petechiae
Management Options
- Supportive care (transfusions during bleeding episodes)
- Avoidance of trauma and elective surgeries
Frequently Asked Questions
How common is Glanzmann thrombasthenia in dogs?
It is rare overall, but certain breeds have higher carrier rates.
Can GT be cured?
No cure exists; management focuses on preventing and treating bleeding episodes.
How is GT diagnosed?
Through DNA testing and specialized platelet function tests.
Should all dogs be tested?
Breeding dogs in at-risk breeds should be tested to prevent producing affected puppies.
What are the first signs?
Unusual or prolonged bleeding after minor injuries or surgery.
Condition Details
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Typical Age of Onset
Puppyhood
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Testing Available
Yes
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Diagnosing Methods
Platelet function testing (aggregation studies); Genetic testing
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Preventative Measures
Genetic screening of breeding stock; Avoid breeding carriers
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Related Conditions
von Willebrand disease, Other platelet function disorders