Centronuclear Myopathy
A rare inherited neuromuscular disorder causing muscle weakness and atrophy.
Detailed Description
Centronuclear myopathy (CNM) is caused by a mutation in the PTPLA gene, leading to abnormal muscle fiber development. Affected puppies show generalized muscle weakness, abnormal gait, and exercise intolerance. Severity varies; some dogs are euthanized due to poor quality of life.
Common Symptoms
- Generalized muscle weakness
- Stilted gait
- Exercise intolerance
- Muscle atrophy
- Megaesophagus (in some cases)
Management Options
- Supportive care
- Physical therapy
- Nutritional support
Frequently Asked Questions
Can CNM be prevented?
Yes, through genetic testing and responsible breeding.
Is there a cure?
No cure; only supportive management.
How early can it be detected?
As early as 2 months with genetic testing.
Condition Details
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Typical Age of Onset
2–5 months
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Testing Available
Yes
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Diagnosing Methods
Genetic testing; Muscle biopsy (histopathology)
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Preventative Measures
Genetic testing and breeding management
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Related Conditions
Muscular dystrophy, Myasthenia gravis