Uveodermatologic Syndrome
Uveodermatologic syndrome is a rare but serious autoimmune disorder causing inflammation of the eyes and depigmentation of skin and hair.
Detailed Description
This syndrome involves immune-mediated attack on melanocytes, leading to uveitis (eye inflammation), skin depigmentation, and sometimes blindness. It is most common in certain breeds and can be life-threatening if not treated aggressively.
Common Symptoms
- Red, painful eyes
- Vision loss
- Skin and nose depigmentation
- Hair whitening
Management Options
- Aggressive immunosuppressive therapy (corticosteroids, cyclosporine)
- Supportive ophthalmic care
Frequently Asked Questions
Is uveodermatologic syndrome curable?
No, but it can sometimes be managed with immunosuppression.
Are only certain breeds affected?
No, but some breeds are more commonly affected.
What are the first signs?
Eye redness and pigment loss on the nose or eyelids.
Condition Details
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Typical Age of Onset
1–4 years
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Testing Available
No
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Diagnosing Methods
Ophthalmic examination; Skin biopsy; Exclusion of infectious causes
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Preventative Measures
Avoid breeding affected dogs
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Related Conditions
Vitiligo, SARDS, Other causes of uveitis