Systemic Lupus Erythematosus
Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder that can affect multiple organ systems, including joints, skin, blood, and kidneys.
Detailed Description
SLE is characterized by the production of autoantibodies against nuclear and cytoplasmic antigens, leading to multisystemic inflammation. Clinical signs are variable and may include polyarthritis, skin lesions, anemia, and renal involvement. Diagnosis is based on clinical criteria and laboratory testing.
Common Symptoms
- Shifting leg lameness
- Fever
- Skin lesions
- Oral ulcers
- Anemia
- Proteinuria
Management Options
- Immunosuppressive therapy (corticosteroids, azathioprine)
- Supportive care
Frequently Asked Questions
Is SLE common in dogs?
It is rare overall but more common in certain breeds.
What are the first signs of SLE?
Lameness, fever, and skin changes are common early signs.
Can SLE be cured?
No, but it can often be managed with immunosuppressive drugs.
Condition Details
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Typical Age of Onset
Young to middle-aged adults (2–6 years)
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Testing Available
Yes
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Diagnosing Methods
ANA (antinuclear antibody) test; Clinical criteria; Exclusion of other diseases
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Preventative Measures
Early recognition and management
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Related Conditions
Rheumatoid arthritis, Immune-mediated polyarthritis, Autoimmune hemolytic anemia