Samoyed Hereditary Glomerulopathy
A severe, inherited kidney disease primarily affecting male Samoyeds, leading to progressive renal failure, often in early life.
Detailed Description
Samoyed Hereditary Glomerulopathy is caused by mutations in the COL4A5 gene, affecting type IV collagen in the glomerular basement membrane. This results in proteinuria, progressive glomerulosclerosis, and eventual renal failure. Female carriers may show mild symptoms, but males are most severely affected, often dying before 15 months of age.
Common Symptoms
- Proteinuria (excess protein in urine)
- Weight loss
- Lethargy
- Increased thirst and urination
- Vomiting
- Anorexia
- Hypertension
Management Options
- Supportive care (dietary management, ACE inhibitors)
- Renal transplantation (rarely performed)
Frequently Asked Questions
Can female Samoyeds be affected?
Females can be carriers and may show mild symptoms, but severe disease is rare.
Is there a cure?
No cure; management is supportive.
How is it inherited?
X-linked dominant; males with the mutation are affected, females are carriers.
Can it be prevented?
Yes, through genetic testing and responsible breeding.
What is the earliest sign?
Proteinuria in a puppy.
Condition Details
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Typical Age of Onset
3-15 months (puppies and young dogs)
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Testing Available
Yes
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Diagnosing Methods
Urinalysis; Serum biochemistry; Renal biopsy; Genetic testing
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Preventative Measures
Genetic screening of breeding stock; Avoid breeding carriers
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Related Conditions
Other forms of juvenile nephropathy, Immune-mediated glomerulonephritis