Renal Amyloidosis
Renal amyloidosis is a hereditary condition in which abnormal protein (amyloid) deposits accumulate in the kidneys, leading to chronic kidney failure.
Detailed Description
Renal amyloidosis is characterized by the deposition of amyloid in the glomeruli, impairing kidney function. This leads to proteinuria, progressive renal insufficiency, and ultimately kidney failure. The disease is progressive and life-threatening, with no cure.
Common Symptoms
- Increased thirst and urination
- Weight loss
- Lethargy
- Proteinuria
- Edema in advanced cases
Management Options
- Supportive care (fluid therapy, renal diets)
- ACE inhibitors to reduce proteinuria
Frequently Asked Questions
Is there a genetic test for amyloidosis?
Not currently, but research is ongoing.
Can early screening improve outcomes?
Early detection allows for supportive care, but does not alter the progressive nature of the disease.
Should affected dogs be bred?
No, affected and carrier dogs should be excluded from breeding programs.
Condition Details
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Typical Age of Onset
3 to 7 years (middle-aged), but can occur earlier
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Testing Available
Yes
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Diagnosing Methods
Bloodwork (BUN, creatinine, albumin); Urinalysis (proteinuria); Renal biopsy for confirmation
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Preventative Measures
Avoid breeding affected or closely related dogs; Early screening in breeding stock
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Related Conditions
Glomerulonephritis, Chronic kidney disease