Protein-Losing Nephropathy
Protein-Losing Nephropathy (PLN) is a kidney disorder causing excessive protein loss in urine, leading to low blood protein, edema, and risk of kidney failure.
Detailed Description
PLN is most often due to immune-mediated glomerulonephritis, where immune complexes damage the glomeruli, resulting in proteinuria and progressive renal dysfunction. It can lead to edema, hypertension, and eventually end-stage renal disease if untreated. Early detection and management are crucial for improving quality of life.
Common Symptoms
- Increased thirst and urination
- Weight loss
- Edema (limbs, abdomen)
- Lethargy
- Hypertension
Management Options
- ACE inhibitors (reduce proteinuria)
- Low-protein, low-phosphorus diet
- Immunosuppressive therapy
- Supportive care (fluids, anti-hypertensives)
Frequently Asked Questions
Can PLN be detected early?
Yes, with annual urine protein screening.
Is PLN always fatal?
It is progressive, but early treatment can extend quality of life.
Is there a genetic test for PLN?
Not yet, but research is ongoing.
Can PLN and PLE occur together?
Yes, and this worsens prognosis.
What is the best diet for PLN?
Low-protein, low-phosphorus, and high-quality protein diets are recommended.
Condition Details
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Typical Age of Onset
4 to 8 years
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Testing Available
Yes
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Diagnosing Methods
Urinalysis (persistent proteinuria); Urine protein:creatinine ratio; Blood chemistry (azotemia, hypoalbuminemia); Renal biopsy
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Preventative Measures
Annual urine screening from age 3–4; Breeding only from dogs with normal urine protein levels
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Related Conditions
Protein-Losing Enteropathy, Chronic kidney disease