Protein-Losing Enteropathy
Protein-Losing Enteropathy (PLE) is a gastrointestinal disorder where proteins are lost from the intestines, leading to low blood protein levels and potentially life-threatening complications.
Detailed Description
Common Symptoms
- Chronic diarrhea
- Weight loss
- Edema (limbs, abdomen)
- Ascites
- Lethargy
Management Options
- Immunosuppressive drugs (e.g., corticosteroids)
- Dietary management (low-fat, highly digestible diets)
- Antibiotics if secondary infection
- Supportive care (fluid therapy, plasma transfusions)
Frequently Asked Questions
Is PLE curable in dogs?
No, but it can often be managed long-term with medication and diet.
Should all dogs be screened for PLE?
Annual bloodwork is recommended for at-risk breeds, especially after age 3–4.
Can PLE be prevented by breeding?
Responsible breeding may reduce risk, but no genetic test is currently available.
How quickly does PLE progress?
Progression can be rapid or gradual; early detection improves outcomes.
Are there early signs unique to certain breeds?
Subtle edema and mild, chronic diarrhea are often first noticed in predisposed breeds.
Condition Details
Typical Age of Onset
4 to 7 years
Testing Available
Yes
Diagnosing Methods
Serum albumin and globulin levels; Fecal alpha-1 protease inhibitor test; Abdominal ultrasound; Intestinal biopsy
Preventative Measures
Early detection and screening in at-risk dogs
Related Conditions
Protein-Losing Nephropathy, Inflammatory Bowel Disease, Intestinal lymphoma