Progressive Neuronal Abiotrophy
A rare, inherited neurodegenerative disorder affecting the cerebellum, leading to progressive loss of coordination.
Detailed Description
Progressive Neuronal Abiotrophy (PNA) is characterized by premature degeneration of neurons in the cerebellum, resulting in ataxia, tremors, and abnormal gait. The disease is progressive and ultimately fatal, with affected dogs showing worsening neurological signs over time. The underlying cause is genetic, with a suspected autosomal recessive inheritance.
Common Symptoms
- Ataxia
- Intention tremors
- Head bobbing
- Wide-based stance
- Falling
- Difficulty walking
Management Options
- Supportive care
Frequently Asked Questions
Can PNA be cured?
No, there is currently no cure; management is supportive only.
Is there a DNA test?
No commercial test is available; diagnosis is clinical and post-mortem.
Should affected dogs be bred?
No, affected dogs and their close relatives should not be bred.
How quickly does the disease progress?
Signs worsen over weeks to months, leading to euthanasia in severe cases.
Are there any early signs?
Yes, puppies may show unsteady gait and tremors as early as 6 weeks.
Condition Details
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Typical Age of Onset
6 weeks to 6 months
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Testing Available
No
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Diagnosing Methods
Neurological examination; MRI to rule out other causes; Post-mortem histopathology
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Preventative Measures
Avoid breeding affected dogs and known carriers; Maintain detailed pedigree records
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Related Conditions
Cerebellar hypoplasia, Intoxication