Primary Hyperparathyroidism
Primary hyperparathyroidism is an endocrine disorder characterized by excessive secretion of parathyroid hormone, leading to high blood calcium levels. It is most often caused by a benign tumor of the parathyroid gland.
Detailed Description
Common Symptoms
- Increased thirst
- Increased urination
- Lethargy
- Decreased appetite
- Muscle weakness
- Urinary tract stones
Management Options
- Surgical removal of affected parathyroid gland(s)
- Medical management for mild cases or pre-surgical stabilization
- Monitoring and management of calcium levels post-surgery
Frequently Asked Questions
Is primary hyperparathyroidism inherited in dogs?
In some breeds, such as the Keeshond, primary hyperparathyroidism is inherited in an autosomal dominant pattern with incomplete penetrance.
What are the first signs of primary hyperparathyroidism?
Early signs often include increased drinking and urination, but may be subtle and detected only through routine bloodwork.
Can primary hyperparathyroidism be prevented?
Responsible breeding using genetic testing can reduce the incidence in predisposed breeds.
Is surgery curative for primary hyperparathyroidism?
Yes, surgical removal of the affected gland is usually curative if performed before significant organ damage occurs.
How often should at-risk dogs be screened for primary hyperparathyroidism?
Annual blood calcium checks are recommended for middle-aged and older dogs in predisposed breeds.
Condition Details
Typical Age of Onset
Middle-aged to older dogs (average 8–11 years)
Testing Available
Yes
Diagnosing Methods
Blood tests for calcium and PTH; Ultrasound of parathyroid glands; Genetic testing
Preventative Measures
Genetic screening of breeding stock; Early blood calcium screening in at-risk dogs
Related Conditions
Secondary hyperparathyroidism, Hypercalcemia of malignancy, Chronic kidney disease