Primary Hyperoxaluria
Primary hyperoxaluria is a rare inherited metabolic disorder causing excessive oxalate production, leading to kidney and urinary tract stones.
Detailed Description
This genetic defect in glyoxylate metabolism results in high urinary oxalate and formation of calcium oxalate stones. It can cause urinary obstruction, kidney damage, and renal failure, especially in young dogs.
Common Symptoms
- Straining to urinate
- Blood in urine
- Frequent urination
- Urinary obstruction
- Signs of kidney failure
Management Options
- Dietary management
- Increased water intake
- Medications to reduce stone formation
- Surgical removal of stones
Frequently Asked Questions
Is primary hyperoxaluria common?
It is rare, but some breeds have a breed-specific mutation.
Can primary hyperoxaluria be cured?
No cure exists; it is managed with diet and supportive care.
How is it diagnosed?
Through genetic testing and urinalysis.
Should dogs be tested for primary hyperoxaluria?
Yes, especially breeding dogs in affected breeds.
What are early signs?
Urinary issues in young dogs, such as frequent urination or blood in urine.
Condition Details
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Typical Age of Onset
1–2 years
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Testing Available
Yes
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Diagnosing Methods
Urinalysis; Abdominal ultrasound; Genetic testing
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Preventative Measures
Genetic testing of breeding dogs; Avoiding breeding carriers
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Related Conditions
Other causes of urinary stones