Musladin-Lueke Syndrome
Musladin-Lueke Syndrome (MLS) is a rare, breed-specific genetic disorder in Beagles causing abnormal connective tissue development, resulting in stiff skin, joint contractures, and distinctive facial features.
Detailed Description
MLS is caused by a mutation in the ADAMTSL2 gene, leading to abnormal collagen and elastin fibers. Affected dogs exhibit thick, tight skin, shortened outer toes, joint stiffness, and a characteristic 'tiptoe' gait. The syndrome is unique to Beagles and can impact quality of life but is not typically life-threatening.
Common Symptoms
- Stiff, thick skin
- Shortened outer toes
- Joint contractures
- Broad, flat skull
- Slanted eyes
Management Options
- Supportive care including physical therapy
- Pain management
Frequently Asked Questions
Is MLS unique to Beagles?
Yes, it is only documented in Beagles.
Can MLS be prevented?
Yes, through responsible breeding and genetic testing.
Condition Details
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Typical Age of Onset
Signs present from birth or early puppyhood
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Testing Available
Yes
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Diagnosing Methods
Clinical examination; Genetic testing
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Preventative Measures
Genetic testing of breeding stock
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Related Conditions
Ehlers-Danlos syndrome