Mucopolysaccharidosis Type IIIB
Mucopolysaccharidosis Type IIIB (MPS IIIB) is a rare, inherited lysosomal storage disorder caused by a deficiency of the enzyme alpha-N-acetylglucosaminidase, leading to progressive neurological decline.
Detailed Description
Common Symptoms
- Progressive ataxia
- Behavioral changes
- Loss of learned behaviors
- Seizures
- Visual impairment
- Incontinence
Management Options
- Supportive care
- Physical therapy
- Environmental modifications
- Anti-seizure medications
Frequently Asked Questions
Can MPS IIIB be prevented?
Yes, through DNA testing and responsible breeding, affected puppies can be avoided.
Is there a cure or effective treatment?
No cure exists; management is supportive only.
How early can carriers be identified?
Carriers can be identified at any age via DNA testing.
Are all dogs at risk?
Only those inheriting two copies of the mutated gene are affected, but carrier frequency can be high in some breeds.
What should I do if my dog is diagnosed?
Work with your veterinarian for supportive care and consider genetic counseling for breeding decisions.
Condition Details
Typical Age of Onset
2–4 years
Testing Available
Yes
Diagnosing Methods
Genetic testing; Clinical neurological examination; MRI; Urine glycosaminoglycan analysis
Preventative Measures
DNA testing of breeding stock; Avoid breeding carriers together
Related Conditions
Other lysosomal storage diseases, Epilepsy, Degenerative myelopathy