MDR1 Drug Sensitivity
MDR1 Drug Sensitivity is caused by a genetic mutation that leads to increased sensitivity to certain drugs, resulting in potentially severe or fatal adverse reactions.
Detailed Description
The MDR1 gene encodes P-glycoprotein, a transporter that protects the brain from certain drugs. A mutation in this gene results in a defective protein, allowing drugs like ivermectin, loperamide, and some chemotherapy agents to accumulate in the brain, causing neurotoxicity.
Common Symptoms
- Ataxia
- Tremors
- Seizures
- Coma
- Death (after drug exposure)
Management Options
- Supportive care for toxicity
- Avoidance of contraindicated drugs
Frequently Asked Questions
Which drugs are dangerous for MDR1 mutant dogs?
Ivermectin, loperamide, certain chemotherapy agents, and others.
Should all dogs be tested for MDR1?
Yes, especially before administering at-risk drugs.
Can carriers have reactions?
Usually only homozygous mutants are severely affected, but caution is advised.
Condition Details
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Typical Age of Onset
Any age (upon drug exposure)
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Testing Available
Yes
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Diagnosing Methods
Genetic testing; Clinical history of drug exposure and symptoms
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Preventative Measures
Genetic testing before drug administration; Inform veterinarians of MDR1 status
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Related Conditions
Other causes of acute neurologic signs