Malignant Histiocytosis
A highly aggressive cancer originating from histiocytes, most commonly affecting Flat-Coated Retrievers.
Detailed Description
Malignant histiocytosis is a rapidly progressive and often fatal cancer involving the proliferation of histiocytes, typically affecting multiple organs. It can present as localized histiocytic sarcoma or as a disseminated, multicentric disease. The condition is genetically influenced and has a strong breed predisposition in Flat-Coated Retrievers.
Common Symptoms
- Lethargy
- Weight loss
- Lameness
- Swelling of limbs or organs
- Respiratory distress
- Neurological signs
Management Options
- Surgical excision if localized
- Chemotherapy
- Palliative care
Frequently Asked Questions
Is this cancer inherited?
There is a strong genetic predisposition, but the exact inheritance is not fully understood.
Can early screening help?
There is no effective screening; early detection is difficult due to rapid progression.
Condition Details
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Typical Age of Onset
6–9 years
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Testing Available
No
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Diagnosing Methods
Imaging (X-ray, ultrasound, CT/MRI); Cytology; Biopsy; Immunohistochemistry
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Preventative Measures
Avoid breeding affected dogs; Breed health screening
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Related Conditions
Lymphoma, Other soft tissue sarcomas