Leonberger Polyneuropathy
A hereditary neurological disorder causing progressive weakness and muscle atrophy, primarily affecting the peripheral nerves.
Detailed Description
Common Symptoms
- Exercise intolerance
- Weakness, especially in hind limbs
- Muscle atrophy
- Laryngeal paralysis
- Gait abnormalities
Management Options
- Supportive care
- Physical therapy
- Mobility aids
- Weight management
Frequently Asked Questions
Can Leonberger Polyneuropathy be cured?
No, it is a progressive genetic disorder; treatment is supportive only.
How is Leonberger Polyneuropathy inherited?
It is inherited in an autosomal recessive manner; both parents must be carriers for offspring to be affected.
What is the earliest sign of Leonberger Polyneuropathy?
Hind limb weakness and exercise intolerance, often before age 5.
Should all Leonbergers be tested for LPN?
Yes, especially breeding dogs should be tested for LPN1 and LPN2 mutations.
Is LPN the same as laryngeal paralysis?
Laryngeal paralysis can be a symptom of LPN, but not all laryngeal paralysis is due to LPN.
Condition Details
Typical Age of Onset
1.5–8 years
Testing Available
Yes
Diagnosing Methods
Clinical neurological examination; Electromyography (EMG); Nerve conduction studies; Genetic testing
Preventative Measures
Genetic testing of breeding stock; Avoid breeding carriers or affected dogs
Related Conditions
Laryngeal paralysis from other causes, Degenerative myelopathy