Lagotto Storage Disease
Lagotto Storage Disease (LSD) is a severe, inherited neurodegenerative disorder unique to the Lagotto Romagnolo, causing progressive ataxia and neurological decline.
Detailed Description
LSD is caused by a mutation in the ATG4D gene, leading to abnormal accumulation of cellular waste in neurons. This results in progressive cerebellar dysfunction, ataxia, behavioral changes, and is ultimately fatal. There is no cure, and the disease significantly impacts quality of life.
Common Symptoms
- Progressive ataxia
- Tremors
- Behavioral changes
- Difficulty walking
- Loss of coordination
- Seizures
Management Options
- Supportive care
Frequently Asked Questions
Can LSD be prevented?
Yes, through genetic testing and responsible breeding.
Is there a cure?
No, only supportive care is possible.
How early can it be detected?
DNA testing can identify carriers and affected puppies before symptoms.
Are all Lagottos at risk?
Only those inheriting two copies of the mutated gene are affected.
What should I do if my Lagotto shows symptoms?
Seek veterinary neurological evaluation and confirm with genetic testing.
Condition Details
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Typical Age of Onset
4 months to 4 years (most commonly before 2 years)
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Testing Available
Yes
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Diagnosing Methods
Genetic testing; Neurological examination; MRI; Histopathology (post-mortem)
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Preventative Measures
Genetic testing of breeding dogs; Avoid breeding carriers together
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Related Conditions
Other cerebellar ataxias, Idiopathic epilepsy