Inherited Polyneuropathy
A breed-specific hereditary neurological disorder causing progressive weakness and loss of coordination.
Detailed Description
Inherited polyneuropathy is caused by a mutation in the NDRG1 gene, leading to degeneration of peripheral nerves. Affected dogs develop muscle weakness, ataxia, and exercise intolerance, often progressing to severe mobility impairment. There is no cure, and management is supportive.
Common Symptoms
- Weakness
- Ataxia
- High-stepping gait
- Exercise intolerance
- Voice changes
- Muscle atrophy
Management Options
- Supportive care
- Physical therapy
Frequently Asked Questions
Is there a cure for inherited polyneuropathy?
No; management is supportive only.
How is it inherited?
Autosomal recessive; both parents must be carriers.
Can it be prevented?
Yes, through genetic testing and responsible breeding.
Condition Details
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Typical Age of Onset
6 months to 2 years
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Testing Available
Yes
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Diagnosing Methods
Neurological examination; Electromyography (EMG); Nerve biopsy; Genetic testing
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Preventative Measures
Genetic testing of breeding stock; Avoid breeding carriers
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Related Conditions
Laryngeal paralysis, Other polyneuropathies