Histiocytic Sarcoma
Histiocytic sarcoma is a highly aggressive cancer of immune system cells, particularly prevalent in Bernese Mountain Dogs.
Detailed Description
Histiocytic sarcoma is a malignant tumor arising from dendritic cells or macrophages, often affecting multiple organs such as the spleen, liver, lungs, lymph nodes, and bone marrow. The disease progresses rapidly, leading to organ failure and death, and is a leading cause of mortality in certain breeds.
Common Symptoms
- Lethargy
- Weight loss
- Lameness
- Swelling
- Organ enlargement
- Respiratory distress
- Anemia
Management Options
- Surgical removal (if localized)
- Chemotherapy
- Palliative care
Frequently Asked Questions
Is histiocytic sarcoma hereditary?
There is a strong familial predisposition, but no single gene has been identified; inheritance is likely polygenic.
Can early detection improve survival?
Early detection of localized tumors may allow surgical removal and slightly longer survival, but overall prognosis remains poor.
Are there screening tests available?
No genetic screening is available; regular veterinary exams and prompt investigation of symptoms are recommended.
Condition Details
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Typical Age of Onset
6-8 years
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Testing Available
No
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Diagnosing Methods
Imaging (X-ray, ultrasound, CT/MRI); Cytology/biopsy; Immunohistochemistry
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Preventative Measures
Early detection and removal of localized tumors
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Related Conditions
Lymphoma, Other soft tissue sarcomas