Hereditary Nephritis
A severe inherited kidney disease leading to progressive renal failure, often at a young age.
Detailed Description
Hereditary nephritis is caused by a genetic defect in type IV collagen, resulting in abnormal glomerular basement membranes. This leads to proteinuria, progressive kidney dysfunction, and ultimately renal failure. The disease is rapidly progressive and fatal, with most affected dogs dying young.
Common Symptoms
- Excessive thirst
- Excessive urination
- Weight loss
- Poor growth
- Vomiting
- Lethargy
- Anorexia
Management Options
- Supportive care
- Dietary management
- ACE inhibitors
Frequently Asked Questions
Can hereditary nephritis be cured?
No, only supportive care is available; prognosis is poor.
How early can it be detected?
As early as 6 months with urine testing.
Should all dogs be screened?
Yes, especially breeding dogs.
Is there a genetic test?
Yes, but not all mutations are detected.
Can carriers be bred safely?
No, carriers should not be bred.
Condition Details
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Typical Age of Onset
6 months to 3 years
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Testing Available
Yes
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Diagnosing Methods
Urinalysis; Blood chemistry; Renal biopsy; Genetic testing
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Preventative Measures
Genetic screening of breeding stock; Avoid breeding affected or carrier dogs
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Related Conditions
Polycystic Kidney Disease, Amyloidosis