Goniodysgenesis and Glaucoma
Goniodysgenesis is a developmental abnormality of the anterior chamber angle of the eye, predisposing Border Collies to primary glaucoma and vision loss.
Detailed Description
Goniodysgenesis is characterized by abnormal development of the iridocorneal angle, impeding aqueous humor drainage and increasing intraocular pressure, which can lead to glaucoma and blindness. A mutation in the OLFML3 gene has been identified in Border Collies.
Common Symptoms
- None in early stages
- Eye pain
- Redness
- Vision loss
- Enlarged globe
Management Options
- Medical management (topical medications)
- Surgical intervention for glaucoma
Frequently Asked Questions
How common is goniodysgenesis in Border Collies?
Up to 30% in some lines.
Can glaucoma be prevented?
Risk can be reduced by screening and selective breeding.
What are the first signs of glaucoma?
Eye pain, redness, vision loss.
Is there a genetic test?
Yes, for the OLFML3 mutation.
How is goniodysgenesis diagnosed?
Gonioscopy by a veterinary ophthalmologist.
Condition Details
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Typical Age of Onset
Goniodysgenesis: congenital; glaucoma: young to middle-aged adults
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Testing Available
Yes
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Diagnosing Methods
Gonioscopy; Intraocular pressure measurement; Genetic testing
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Preventative Measures
Genetic testing; Regular eye exams
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Related Conditions
Other causes of glaucoma, Uveitis