Glycogen Storage Disease Type IIIa
Glycogen Storage Disease Type IIIa (GSD IIIa) is a rare inherited metabolic disorder causing abnormal glycogen accumulation in liver and muscle tissues.
Detailed Description
GSD IIIa is caused by a deficiency of the glycogen debranching enzyme due to an AGL gene mutation, leading to progressive liver dysfunction and muscle weakness. Affected dogs may develop hypoglycemia, hepatomegaly, and exercise intolerance, and the disease is progressive and potentially fatal.
Common Symptoms
- Exercise intolerance
- Muscle weakness
- Enlarged liver (hepatomegaly)
- Poor growth
- Hypoglycemic episodes
Management Options
- Supportive care (frequent feeding, high-protein diet)
- Avoidance of fasting
Frequently Asked Questions
Can GSD IIIa be cured?
No, only supportive care is available.
How can I prevent GSD IIIa in my puppies?
Test breeding dogs and avoid carrier-to-carrier matings.
What are early signs of GSD IIIa?
Poor growth, lethargy, and enlarged abdomen in young dogs.
Condition Details
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Typical Age of Onset
Juvenile to young adult (as early as 5 months)
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Testing Available
Yes
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Diagnosing Methods
Genetic testing; Liver biopsy (histopathology); Bloodwork (elevated liver enzymes, hypoglycemia)
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Preventative Measures
DNA testing of breeding dogs; Avoid breeding carriers
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Related Conditions
Other metabolic or hepatic diseases