Familial Shar-Pei Fever
Familial Shar-Pei Fever (FSF) is a breed-specific autoinflammatory disorder characterized by recurrent episodes of fever and swelling, often leading to amyloidosis and kidney failure.
Detailed Description
Common Symptoms
- Recurrent fever
- Swelling of hocks or muzzle
- Lethargy
- Anorexia
- Progression to proteinuria
- Kidney failure
Management Options
- NSAIDs for fever episodes
- Colchicine to reduce amyloid deposition
- Supportive care for renal failure
Frequently Asked Questions
Can FSF be cured?
No, but symptoms can be managed and amyloidosis delayed with medication.
Is FSF contagious?
No, it is a genetic, non-infectious condition.
Should Shar-Pei with FSF be bred?
No, affected dogs should not be bred due to heritability.
How is FSF different from regular fever?
FSF is recurrent, breed-specific, and often accompanied by hock swelling.
What is the long-term outlook?
With early management, some dogs live normal lives; others develop fatal kidney failure.
Condition Details
Typical Age of Onset
6 months to 3 years, but can occur at any age
Testing Available
No
Diagnosing Methods
Clinical history and breed; Exclusion of infectious causes; Bloodwork (inflammatory markers, proteinuria); Renal biopsy for amyloidosis confirmation
Preventative Measures
Early colchicine therapy in recurrent cases; Avoid breeding affected dogs
Related Conditions
Amyloidosis, Infectious fever, Immune-mediated polyarthritis