Familial Nephropathy
Familial nephropathy is a fatal, inherited kidney disease causing early-onset renal failure in affected dogs.
Detailed Description
This condition is caused by a mutation in the COL4A4 gene, leading to defective type IV collagen in the glomerular basement membrane. Affected dogs develop proteinuria and progressive kidney failure, typically resulting in death before two years of age. There is no cure, and management is limited to supportive care.
Common Symptoms
- Excessive thirst and urination
- Poor growth
- Vomiting
- Weight loss
- Lethargy
Management Options
- Supportive care
- ACE inhibitors
- Dietary management
Frequently Asked Questions
Can familial nephropathy be cured?
No, there is no cure; only supportive care is possible.
Is there a test for carriers?
Yes, a DNA test is available to identify carriers and affected dogs.
How common is familial nephropathy?
Carrier rates can be significant in some breeds, but affected dogs are rare due to genetic testing.
Should all dogs be tested?
All breeding dogs in at-risk breeds should be tested to prevent producing affected puppies.
What are the first signs?
Excessive urination and poor growth in puppies are early warning signs.
Condition Details
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Typical Age of Onset
6 months–2 years
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Testing Available
Yes
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Diagnosing Methods
Genetic testing; Urinalysis; Renal biopsy
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Preventative Measures
DNA testing of breeding dogs; Do not breed carriers together
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Related Conditions
Other forms of chronic kidney disease