Factor XI Deficiency
A hereditary bleeding disorder caused by deficiency of clotting Factor XI, leading to prolonged bleeding after injury or surgery.
Detailed Description
Factor XI deficiency, also known as Hemophilia C, leads to impaired blood clotting and prolonged bleeding after trauma or surgery. It is inherited as an autosomal recessive trait and can be detected with specific blood tests or DNA testing. Clinical signs may not appear until the dog is injured or undergoes surgery.
Common Symptoms
- Prolonged bleeding after surgery
- Prolonged bleeding after trauma
- Rarely spontaneous bleeding
Management Options
- Blood transfusions for severe bleeding
- Avoid trauma and surgery if possible
Frequently Asked Questions
Is there a DNA test?
Yes, and it is recommended for breeding dogs.
Can affected dogs live normal lives?
Yes, if trauma and surgery are avoided.
Is it common?
Carrier rate is 2–5% in some populations.
What are the signs?
Prolonged bleeding after injury or surgery.
Should carriers be bred?
No, to avoid producing affected puppies.
Condition Details
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Typical Age of Onset
Congenital; clinical signs may not appear until trauma or surgery
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Testing Available
Yes
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Diagnosing Methods
Coagulation profile (prolonged aPTT); DNA test for F11 mutation
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Preventative Measures
DNA testing of breeding dogs; Avoid breeding carriers
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Related Conditions
von Willebrand disease, Other bleeding disorders