Factor VII Deficiency
Factor VII deficiency is a hereditary bleeding disorder due to insufficient production of clotting Factor VII, leading to increased bleeding risk.
Detailed Description
This condition is caused by a mutation in the F7 gene and is inherited as an autosomal recessive trait. Affected dogs may be asymptomatic or experience excessive bleeding after trauma or surgery, with a risk of life-threatening hemorrhage.
Common Symptoms
- Prolonged bleeding after injury or surgery
- Occasional spontaneous bleeding
Management Options
- Blood transfusions for severe bleeding
- Avoidance of trauma or surgery when possible
Frequently Asked Questions
Can carriers show symptoms?
No, only homozygous affected dogs show clinical signs.
Is there a cure?
No, but bleeding episodes can be managed with supportive care.
Condition Details
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Typical Age of Onset
At birth, but often detected after surgery or trauma
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Testing Available
Yes
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Diagnosing Methods
Prolonged prothrombin time (PT); Genetic testing
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Preventative Measures
Genetic testing before breeding; Avoid breeding carriers
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Related Conditions
Von Willebrand disease, Hemophilia A, Hemophilia B