Exocrine Pancreatic Insufficiency
A hereditary disorder where the pancreas fails to produce sufficient digestive enzymes, leading to malabsorption and weight loss.
Detailed Description
Exocrine pancreatic insufficiency (EPI) is most commonly due to pancreatic acinar atrophy, which is believed to be immune-mediated and has a genetic predisposition in certain breeds. The lack of digestive enzymes causes chronic diarrhea, weight loss, and poor coat condition despite a normal or increased appetite.
Common Symptoms
- Chronic diarrhea
- Steatorrhea (greasy stools)
- Weight loss
- Increased appetite
- Poor coat
Management Options
- Lifelong pancreatic enzyme supplementation
- Dietary management (highly digestible, low-fiber diet)
- Antibiotics for secondary small intestinal bacterial overgrowth
Frequently Asked Questions
Is EPI curable?
No, but it is manageable with enzyme supplements.
Can EPI be fatal?
Not if treated; untreated cases can be life-threatening.
Is EPI inherited?
There is a strong genetic predisposition in some breeds.
Condition Details
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Typical Age of Onset
1–5 years (but can occur at any age)
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Testing Available
Yes
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Diagnosing Methods
Serum trypsin-like immunoreactivity (TLI) test; Fecal elastase test
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Preventative Measures
Selective breeding may help
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Related Conditions
Inflammatory bowel disease, Food allergies