Cutaneous Mucinosis
Cutaneous mucinosis is a breed-defining skin condition in Shar-Pei, characterized by excessive mucin (hyaluronic acid) deposition in the skin, contributing to their wrinkled appearance and predisposing to skin infections.
Detailed Description
Shar-Pei have a genetic mutation leading to overproduction of hyaluronic acid, resulting in mucin-filled vesicles within the skin. While this gives the breed its characteristic wrinkles, it also weakens the skin barrier, increasing susceptibility to pyoderma and other dermatological issues.
Common Symptoms
- Loose, wrinkled skin
- Clear vesicles or blisters (mucin-filled)
- Secondary skin infections
Management Options
- Management of secondary infections (antibiotics, topical therapy)
- Immunosuppressive therapy for severe cases
Frequently Asked Questions
Is mucinosis harmful?
Usually not, but can predispose to skin infections.
Can mucinosis be cured?
No, it is a breed trait, but complications can be managed.
Does mucinosis affect all Shar-Pei?
Yes, but severity varies.
Can mucinosis be prevented?
No, but good skin care reduces complications.
Is mucinosis related to FSF?
Both are linked to the same genetic region (HAS2 gene).
Condition Details
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Typical Age of Onset
Puppyhood (wrinkles present at birth)
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Testing Available
Yes
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Diagnosing Methods
Clinical appearance; Skin biopsy (hyaluronic acid staining)
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Preventative Measures
Good skin hygiene; Prompt treatment of skin infections
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Related Conditions
Allergic dermatitis, Other causes of vesicular skin lesions