Copper-Associated Chronic Hepatitis
A chronic liver disease associated with abnormal copper accumulation, reported with increased frequency in some breeds.
Detailed Description
Copper-associated hepatitis is a progressive liver disease caused by abnormal copper metabolism, leading to copper accumulation, hepatocellular injury, inflammation, and fibrosis. Clinical signs are often vague until advanced disease develops, but early detection and management can improve outcomes.
Common Symptoms
- Lethargy
- Poor appetite
- Weight loss
- Jaundice (in advanced cases)
- Ascites
Management Options
- Copper chelation (penicillamine)
- Low-copper diet
- Zinc supplementation
- Supportive liver medications
Frequently Asked Questions
Can copper-associated hepatitis be cured?
It can be managed but not cured; early treatment is key.
How is it diagnosed?
By liver biopsy and copper quantification.
Condition Details
📅
Typical Age of Onset
Middle-aged (4-8 years)
📋
Testing Available
No
🔍
Diagnosing Methods
Bloodwork (elevated liver enzymes); Abdominal ultrasound; Liver biopsy
🛡️
Preventative Measures
Screening of breeding stock; Early liver enzyme monitoring
🔗
Related Conditions
Idiopathic chronic hepatitis, Infectious hepatitis