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Health Condition

Congenital Alopecia

Congenital alopecia is a hereditary condition resulting in partial or complete hairlessness, often associated with dental anomalies, and is a defining trait in certain hairless dog breeds.

Detailed Description

Congenital alopecia, also known as canine ectodermal dysplasia, is caused by a mutation in the FOXI3 gene and is inherited as an autosomal dominant trait with homozygous lethality. It is present at birth and results in permanent hairlessness, often accompanied by dental anomalies such as missing or malformed teeth. The condition increases susceptibility to sunburn, skin injuries, and dental disease, but can be managed with appropriate care.

Common Symptoms

  • Hairlessness or sparse hair on head, feet, and tail
  • Missing or malformed teeth
  • Dry, sensitive skin prone to sunburn and injury

Management Options

  • Skin protection with clothing and sunscreen
  • Regular dental care and cleaning
  • Management of secondary skin infections

Frequently Asked Questions

Is hairlessness in PIOs a disease?

No, it is a breed-defining trait, but it does require special care.

Are all PIOs hairless?

No, there is also a coated variety without these issues.

Can hairless PIOs have dental problems?

Yes, missing or malformed teeth are common.

How do I protect my PIO’s skin?

Use dog-safe sunscreen, protective clothing, and avoid prolonged sun exposure.

Can hairless PIOs be bred together?

No, this can result in lethal gene combinations; always breed hairless to coated.

Condition Details

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Typical Age of Onset

Congenital (present at birth)

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Testing Available

Yes

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Diagnosing Methods

Physical examination; Dental radiographs; Genetic testing for FOXI3 mutation

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Preventative Measures

Responsible breeding to avoid homozygous lethal combinations; Sun protection; Regular dental checkups

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Related Conditions

Alopecia X, Endocrine alopecias