Amyloidosis
Renal amyloidosis is a progressive, often fatal kidney disease resulting from amyloid protein deposition, commonly secondary to FSF in Shar-Pei.
Detailed Description
Amyloidosis in Shar-Pei is typically secondary to chronic inflammation (FSF), leading to amyloid A protein accumulation in the kidneys. This disrupts normal kidney function, causing proteinuria, nephrotic syndrome, and ultimately renal failure.
Common Symptoms
- Excessive thirst and urination
- Weight loss
- Poor appetite
- Edema
- Ascites
- Proteinuria
Management Options
- Supportive renal care (diet, fluids)
- Colchicine to slow amyloid deposition
- ACE inhibitors for proteinuria
Frequently Asked Questions
Is amyloidosis treatable?
Only symptomatically; progression can be slowed but not reversed.
Is amyloidosis always caused by FSF?
In Shar-Pei, most cases are secondary to FSF.
Can amyloidosis be detected early?
Regular urine screening for proteinuria can help.
Is there a genetic test?
No direct test for amyloidosis; FSF genetic risk is under research.
What is the prognosis?
Guarded to poor, especially if diagnosed late.
Condition Details
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Typical Age of Onset
1-5 years
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Testing Available
Yes
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Diagnosing Methods
Urinalysis (proteinuria); Bloodwork (azotemia, hypoalbuminemia); Renal biopsy (Congo red staining for amyloid)
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Preventative Measures
Early intervention in FSF cases; Avoid breeding affected dogs
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Related Conditions
Glomerulonephritis, Chronic kidney disease