Addison’s Disease
Addison’s disease (hypoadrenocorticism) is an autoimmune disorder causing insufficient production of adrenal hormones, which can be life-threatening if untreated.
Detailed Description
Addison’s disease results from immune-mediated destruction of the adrenal cortex, leading to deficient cortisol and aldosterone. Symptoms are often vague and episodic, but can progress to life-threatening Addisonian crisis if untreated. Lifelong hormone replacement is required for management.
Common Symptoms
- Lethargy
- Vomiting
- Diarrhea
- Weight loss
- Poor appetite
- Collapse
- Bradycardia
- Dehydration
Management Options
- Lifelong hormone replacement (prednisone, fludrocortisone or DOCP injections)
- Emergency stabilization for crisis
Frequently Asked Questions
Is Addison’s disease curable?
No, but it is manageable with medication.
How is Addison’s diagnosed?
ACTH stimulation test is the gold standard.
Can Addison’s be fatal?
Yes, if untreated, but prognosis is excellent with therapy.
Is Addison’s inherited?
Yes, there is a genetic predisposition in some breeds.
What are early signs to watch for?
Recurrent vomiting, diarrhea, lethargy, and unexplained collapse.
Condition Details
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Typical Age of Onset
2-6 years
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Testing Available
Yes
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Diagnosing Methods
ACTH stimulation test; Baseline cortisol; Electrolyte panel
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Preventative Measures
No known prevention; Early recognition and treatment
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Related Conditions
Gastroenteritis, Renal disease